A rapid test for the qualitative detection of Pregabalin in human urine. For professional in vitro diagnostic use only.
Pregabalin, sold under the trade name Lyrica®, an analog of the inhibitory neurotransmitter gamma-aminobutyric acid and also of gabapentin, has been used clinically since 2002 as an analgesic, anticonvulsant and anxiolytic agent. It is supplied as the free drug in 25-300mg capsules for oral administration. Adult dose are normally within a range of 50-200mg thrice daily. A single oral labeled dose of pregabalin in humans was eliminated in urine (92%) and feces (<0.1%) over a 4 days period. Urinary excretion products included unchanged drug (90% of the dose), N-Methylpregabalin (0.9%) and others. Single oral 75 or 150mg doses given to a healthy human yielded peak urinary pregabalin concentrations of 151 or 214 μg/mL, respectively, in the first 8 hours specimen. Pregabalin urine levels in 57,542 specimens from chronic pain patients averaged 184 μg/mL1,2 .
Materials Provided
