The HSV-2 IgG/IgM Rapid Test Cassette (Serum/Plasma) is a lateral flow chromatographic immunoassay for the qualitative detection of IgG and IgM antibodies to HSV-2 in serum or plasma to aid in the diagnosis of HSV-2 infection.
Herpes Simplex Virus (HSV) is a common pathogen of humans. There are two distinct types of HSV: Types 1 and 2. HSV-1 is usually associated with infection in the oropharyngeal area and eyes while HSV-2 causes mostly genital and neonatal infections.1,2 However, the tissue specificity is not absolute.3 Both HSV-1 and HSV-2 can be found at either site of infection without being specific for one region, i.e., either genital or oropharynx.. Neonatal HSV infection may remain localized or become disseminated. Localized infection may involve skin, eyes, mouth or central nervous system. The infants with neonatal HSV bear the risk of developing severe neurological or ocular sequelae. Detection of antibodies to HSV has been acknowledged to be a screening method for HSV infections. The methods for such antibodies detection include complement fixation, indirect immunofluorescent antibody, plaque neutralization, and ELISA. Antibody of the IgM class is produced during the first 2-3 weeks of infection with HSV and exists only transiently in most patients. The detection of IgM antibodies against HSV help discriminates between primary and recurrent infections. The detection of anti-HSV-2 IgM antibodies enables effective diagnosis of acute or recent HSV-2 infection. The HSV-2 IgG/IgM Rapid Test Cassette (Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of IgG and IgM antibodies to HSV-2 in serum or plasma specimens
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