A rapid test for the qualitative detection of Human Hemoglobin and Transferrin in feces. For professional in vitro diagnostic use only.
Many diseases can cause hidden blood in the feces. This is also known as Fecal Occult Blood (FOB), Human occult Blood, or Human Hemoglobin. In the early stages, gastrointestinal problems such as colon cancer, ulcers, polyps, colitis, diverticulitis, and fissures may not show any visible symptoms, only occult blood. Fecal occult blood testing can provide clues as to subtle blood loss in the gastrointestinal tract. Positive tests ("positive stool") warrant further investigation for a malignancy such as colorectal cancer (that is one of the leading causes of illness and death in the Western word) or gastric cancer. The presence of human hemoglobin in feces is inadequate as a screening test for stomach cancer (upper gastrointestinal disorders), because of human hemoglobin derived from the upper digestive tract is broken down in the intestinal tract (the antigenicity is lost). Detection of fecal Transferrin, which is more resistant to the metabolism in the intestine than that of the Hemoglobin, provides the best complementary way of diagnosing the disease in the upper digestive tract. Transferrin is a blood plasma protein for iron ion delivery. Although iron bound to transferring is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool with the highest rate of turnover (25 mg/24 h). Transferrin imbalance can have serious health effects for those with high serum transferring levels. A patient with an increased serum transferring level suffers from iron deficiency anemia that is one of the most important symptoms when a tumor has caused chronic occult bleeding. The FOB/Transferrin Rapid Test Cassette (Feces) is a rapid test to qualitatively detect low levels of Human Hemoglobin and Transferrin in feces. The test uses a double antibody sandwich assay to selectively detect Human Hemoglobin at 10ng/ml or higher and Transferrin at 4ng/ml or higher. In addition, unlike guaiac assays, the accuracy of the test is not affected by the diet of the patients
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